The Dorsky laboratory studies the role of the Wnt signaling pathway in CNS neurogenesis. We use zebrafish as a model organism, focusing on the regulation of Wnt target genes in the CNS by Tcf transcription factors.
The Dorsky Lab
Our current work focuses on neurogenesis in the spinal cord and the hypothalamus, addressing three important questions.
1) Which cells require Wnt/Tcf signaling?
2) What are the molecular targets of Tcf proteins?
3) How does Wnt/Tcf-dependent neurogenesis contribute to physiology and behavior?